解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Endo-beta-1,4-xylanases (EC 3.2.1.8) are the main enzymes involved in the hydrolysis of xylans, the most abundant hemicelluloses in plant biomass. However, the development of efficient endoxylanases for use in biorefinery processes is currently hampered by insufficient knowledge regarding the impact of the cell wall n...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm9004518
更新日期:2009-09-14 00:00:00
abstract::This investigation describes the formulation and characterization of rheologically structured vehicles (RSVs) designed for improved drug delivery to the vagina. Interactive, multicomponent, polymeric platforms were manufactured containing hydroxyethylcellulose (HEC, 5% w/w) polyvinylpyrrolidone (PVP, 4% w/w), Pluronic...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm9003332
更新日期:2009-09-14 00:00:00
abstract::Collagen's biocompatibility, biodegradability and low immunogenicity render it advantageous for extensive application in pharmaceutical or biotechnological disciplines. However, typical collagen extraction from animal or cadaver sources harbors risks including allergenicity and potential sample contamination with path...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm900571b
更新日期:2009-09-14 00:00:00
abstract::Stability of four dissimilar basic proteins (chymotrypsinogen A, ribonuclease A, cytochrome c, lysozyme) in the complex with four polyanions (heparin, poly(vinylsulfate), poly(4-styrene-sulfonate), Nafion) has been studied by differential scanning calorimetry. The polyanions were chosen because of their different char...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm900480t
更新日期:2009-09-14 00:00:00
abstract::A cellulose macromonomer, N-(15-methacryloyloxypentadecanoyl)-tri-O-acetyl-beta-cellulosylamine (CTA-C15-MA (2); M(2)) with number averaged degree of polymerization (DP(n)) = 13), was copolymerized with methyl methacrylate (MMA; M(1)) to give cellulosic copolymer with CTA side chains, PMMA-g-(CTA-C15) (3-A). An absolu...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm900229g
更新日期:2009-08-10 00:00:00
abstract::Surface modification is often needed in tissue engineering to enhance the interaction between cells and synthetic materials and improve the cytocompatibility and cellular functions. In this study, block copolymers of poly(L-lactic acid) and poly(ethyl ethylene phosphate) (PLLA-b-PEEP) were synthesized and used to modi...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm900390k
更新日期:2009-08-10 00:00:00
abstract::Biodegradable polyrotaxanes (PRXs) were synthesized from bis-amino-terminated poly(L-lactide) (PLLA) and alpha-cyclodextrin (alpha-CD), combined with capping by bulky end groups at the amino-termini of PLLA through enzymatically cleavable peptide linkages. The crystalline structure of the PRXs in the solid state was i...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm900440v
更新日期:2009-08-10 00:00:00
abstract::The oxidation reaction of regenerated cellulose fibers mediated by N-hydroxyphthalimide (NHPI) and various cocatalysts at room temperature for different time intervals and various amounts of low concentration sodium hypochlorite solution has been investigated to produce oxidized cellulose (OC), a biocompatible and bio...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm9004854
更新日期:2009-08-10 00:00:00
abstract::The self-assembly properties of fibrous proteins such as collagen are frequently used to form three-dimensional scaffolds. In this study we investigated the effect of nonuniform alternating and static electric-fields on the self-assembly properties of a dilute solution of vimentin. In the presence of both types of fie...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm900398n
更新日期:2009-07-13 00:00:00
abstract::The water-soluble arabinoxylans from wheat flour (high, medium, and low viscosity samples) and rye flour (high viscosity sample) were characterized by (1)H NMR spectroscopy and HPSEC with refractive index, light scattering, and viscometric detectors. These cereal arabinoxylans have recently been used as model arabinox...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm9003767
更新日期:2009-07-13 00:00:00
abstract::The basic physicochemical properties that determine the distribution and fate of synthetic macromolecules in living cells were characterized using fluorescently labeled HPMA (N-(2-hydroxypropyl)methacrylamide) copolymers. Twelve different classes of water-soluble copolymers were created by incorporating eight differen...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm801514x
更新日期:2009-07-13 00:00:00
abstract::The interaction between positively charged poly(amido amine) (PAMAM) dendrimers of generation 4 and DNA has been investigated for two DNA lengths; 2000 basepairs (bp; L = 680 nm) and 4331 bp (L = 1472.5 nm) using a theoretical model by Schiessel for a semiflexible polyelectrolyte and hard spheres. The model was modifi...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm9000662
更新日期:2009-07-13 00:00:00
abstract::Amphiphilic block copolymer self-assembly provides a versatile means to prepare nanoscale micelles in solution. The utilization of these structures as targeted drug delivery vehicles has motivated efforts to prepare bioactive ligand-functionalized polymer micelles. The impact of ligand conjugation on micelle morpholog...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm900149b
更新日期:2009-06-08 00:00:00
abstract::One of the major drawbacks found in most bone tissue engineering approaches developed so far consists in the lack of strategies to promote vascularisation. Some studies have addressed different issues that may enhance vascularisation in tissue engineered constructs, most of them involving the use of growth factors (GF...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm8014973
更新日期:2009-06-08 00:00:00
abstract::Microgels based on poly(vinyl alcohol), PVA, grafted with methacrylate side chains, MA, incorporating N-isopropylacrylamide, NiPAAm, monomer, were prepared by water-in-water emulsion polymerization method. These systems exhibit a spherical shape and a volume-phase transition, that is, shrinking, below physiological te...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm900185u
更新日期:2009-06-08 00:00:00
abstract::Enzymatic glyco-modification of transparent cellulose films with lactose was achieved by nonaqueous biocatalysis, and rat hepatocyte attachment behavior to the lactose-modified cellulose films was investigated. Regenerated cellulose films were incubated with lactose using a surfactant-enveloped cellulase in lithium ch...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm900089j
更新日期:2009-05-11 00:00:00
abstract::Cocontinuous phase structures of immiscible polymers can be developed under appropriate melt-blending conditions. Because of the presence of interfacial tension, such cocontinuous structures start to coarsen when heated to a temperature higher than the melting/softening temperature of both phases. In this study, a met...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm900008d
更新日期:2009-05-11 00:00:00
abstract::Steady state shear flow of different types of cellulose (microcrystalline, spruce sulfite and bacterial) dissolved in 1-ethyl-3-methylimidazolium acetate was studied in a large range of concentrations (0-15%) and temperatures (0-100 degrees C). Newtonian flow was recorded for all experimental conditions; these viscosi...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm801430x
更新日期:2009-05-11 00:00:00
abstract::Tissue engineering approaches for peripheral nerve regeneration employ biodegradable scaffolds coupled with growth factors for improved performance in regeneration of large nerve injuries. Electrospun nanofibers provide a versatile platform for fabrication of scaffolds with extracellular matrix like architecture and i...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm8012499
更新日期:2009-05-11 00:00:00
abstract::A systematic study is carried out to understand how physical and covalent crosslinks affect the mechanical properties of an eight-arm poly(ethyleneglycol)-based hydrogel. Heparin and heparin-binding peptide are used as a physical crosslinker, and an enzymatically cleavable peptide with a cysteine on each end serves as...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm801270k
更新日期:2009-05-11 00:00:00
abstract::Textile chitosan fiber scaffolds were developed and tested in terms of biocompatibility for human bone marrow stromal cells (hBMSCs). A part of the scaffolds was further modified by coating with fibrillar collagen type I in order to biologize the surface. hBMSCs of two donors were used for cell culture experiments in ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm900172m
更新日期:2009-05-11 00:00:00
abstract::This paper shows a simple and effective way to avoid the dissociation of multimeric enzymes by coating their surface with a large cationic polymer (e.g., polyethylenimine (PEI)) by ionic exchange. As model enzymes, glutamate dehydrogenase (GDH) from Thermus thermophilus and formate dehydrogenase (FDH) from Pseudomonas...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm801162e
更新日期:2009-04-13 00:00:00
abstract::New silk-like recombinant proteins, [(AAG)(6)ASTGRGDSPAAS](n) and [(AG)(9)ASTGRGDSPAAS](n), with high cell adhesive activities were designed and produced from E. coli. These are recombinant proteins with characteristic sequences from the silk fibroin of a wild silkworm, Anaphe , and the cell adhesive region, including...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm801439t
更新日期:2009-04-13 00:00:00
abstract::A new, convenient pathway is developed to synthesize highly hydrolytically labile poly(ortho ester amide) (POEA) copolymers that overcomes some of the major weaknesses of the traditional methods of synthesizing poly(ortho esters) and their derivatives. A diamine monomer containing a built-in, stabilized ortho ester gr...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm9000475
更新日期:2009-04-13 00:00:00
abstract::Reversible addition-fragmentation chain transfer (RAFT) radical polymerization, mediated by 4-cyanopentanoic acid dithiobenzoate and 4,4'-azobis(4-cyanovaleric acid) (V-501) in water at 70 degrees C, of biocompatible 2-(methacryloyloxy)ethyl phosphorylcholine (MPC) yields a macro-chain transfer agent (CTA) that was em...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm8014945
更新日期:2009-04-13 00:00:00
abstract::A recombinant silk-elastin-like protein copolymer SELP-47K containing tandemly repeated amino acid sequence blocks from silk, GAGAGS, and elastin, GVGVP, was fabricated into microdiameter fibers using a wet-spinning technique. Raman spectral analysis revealed the formation of antiparallel beta-sheet crystals of the si...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm801296r
更新日期:2009-03-09 00:00:00
abstract::The carboxyl-terminal domain (CTD, residues 146-231) of the HIV-1 capsid (CA) protein plays an important role in the CA-CA dimerization and viral assembly of the human immunodeficiency virus type 1. Disrupting the native conformation of the CA is essential for blocking viral capsid formation and viral replication. Thu...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm801151r
更新日期:2009-02-09 00:00:00
abstract::Alditol bearing chitosans have shown the ability to reduce silver ions in mild conditions and without addition of exogenous reducing agents. The ion reduction induces the formation of a lactone moiety on the polysaccharide (Fetizon reaction) without causing C-C bond cleavage on the polyol. The close and multivalent ar...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm801253c
更新日期:2009-02-09 00:00:00
abstract::Poly(epsilon-caprolactone)/polylactide blend (PCL/PLA) is an interesting biomaterial because PCL and PLA present good complementarity in their physical properties and biodegradability. However, the thermodynamic incompatibility between two component polymers restricts further applications of their blend. In this work,...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm801183f
更新日期:2009-02-09 00:00:00
abstract::Hollow poly(6-O-acryloyl-alpha-D-galactopyranose) (PAGP) nanospheres were prepared in a facile manner using the RAFT (reversible addition fragmentation chain transfer) process. Initially, an amphiphilic block copolymer, poly(lactide)-block-poly(6-O-acryloyl-alpha-D-galactopyranose) (PLA-b-PAGP), was synthesized using ...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm801123b
更新日期:2009-02-09 00:00:00
abstract::A series of structurally diverse polymers, containing either peptide or vinyl-derived backbones, was tested for ice recrystallization inhibition activity, which is commonly associated with antifreeze (glyco)proteins. It was revealed that only polymers bearing hydroxyl groups in the side chain could inhibit ice growth....
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm801069x
更新日期:2009-02-09 00:00:00
abstract::Softwood and hardwood celluloses were oxidized by 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-mediated oxidation. The TEMPO-oxidized cellulose fibers were converted to transparent dispersions in water, which consisted of individual nanofibers 3-4 nm in width. Films were then prepared from the TEMPO-oxidized c...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm801065u
更新日期:2009-01-12 00:00:00
abstract::The controlled delivery of growth factors is a very challenging task because many different issues have to be addressed to develop the best suited system. A wide range of approaches have been employed for the controlled delivery of growth factors by hydrogels. Direct loading, electrostatic interaction, covalent bindin...
journal_title:Biomacromolecules
pub_type: 杂志文章,评审
doi:10.1021/bm801103c
更新日期:2009-01-12 00:00:00
abstract::Type I collagen is explored heavily for use in biomaterials, but the role of other extracellular matrix components in regulating collagen organization is gaining attention. We show that as the ratio of type III to type I collagen increases, fibril diameter decreases. A mixture of the two collagen types results in a mo...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm800888u
更新日期:2009-01-12 00:00:00
abstract::Turbidimetric titration was used to initiate associative intermolecular interactions between a pair of protein molecules, gelatin-A and gelatin-B, having complementary charges that led to pH-induced liquid-liquid phase separation and the formation of complex coacervate. The stoichiometric binding ratio was found to be...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm801160s
更新日期:2009-01-12 00:00:00
abstract::Tiopronin (N-(2-mercaptopropionyl)glycine)-protected gold nanoparticles (TPAu) were cross-linked to collagen via EDC (1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide) coupling. On average, each TPAu forms eight amide bonds with collagen lysine moieties. The resulting gels were studied with environmental SEM, TEM, micr...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm800793z
更新日期:2008-12-01 00:00:00
abstract::Most biopolymers exist in a plasticized state, whether it is naturally with water or unnaturally with glycerol or other suitable polyol, to make a flexible material. We have found that the extent to which a biopolymer can be plasticized is dependent on its molecular and higher order structures outside of simply molecu...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm800759g
更新日期:2008-11-01 00:00:00
abstract::High molecular weight trimethylene carbonate (TMC) and epsilon-caprolactone (CL) (co)polymers were synthesized. Melt pressed (co)polymer films were cross-linked by gamma irradiation (25 kGy or 50 kGy) in vacuum, yielding gel fractions of up to 70%. The effects of copolymer composition and irradiation dose on the cytot...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm8007988
更新日期:2008-11-01 00:00:00
abstract::Properties of Aloe vera galacturonate hydrogels formed via Ca(2+) crosslinking have been studied in regard to key parameters influencing gel formation including molecular weight, ionic strength, and molar ratio of Ca(2+) to COO(-) functionality. Dynamic oscillatory rheology and pulsed field gradient NMR (PFG-NMR) stud...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm8008457
更新日期:2008-11-01 00:00:00
abstract::Chitosan hydrogel microspheres were obtained by cross-linking chitosan in its inverse emulsion using genipin as cross-linker. The genipin-cross-linked chitosan microspheres (ChGp) swell significantly in water at pH values below 6.5 and shrink to a smaller extent at pH values above 6.5. ChGp microspheres bind heparin i...
journal_title:Biomacromolecules
pub_type: 杂志文章
doi:10.1021/bm800724q
更新日期:2008-11-01 00:00:00